Cocle is located among the central provinces, in the south east of the Isthmus. Bordered on the north by Colon, to the south by Herrera and the Pacific Ocean, to the east by Panama, and to the west by Veraguas. Its capital is Penenome. This province is made up of 6 districts (Aguadulce, Anton, La Pintanada, Nata, Ola, and Penenome).

The province offers beautiful coastal areas such as the Pacific beaches of Santa Clara and Farallon as well as El Valle de Anton, which is the only place in our country where one can admire square trees. El Valle was the crater of a giant volcano that later became a lake, and still later marshland. The thermal waters in the region are due to these marshes. Additionally one can see the Sleeping Indian Maiden, who, according to legend, was a young girl named Flower of the Air who fell in love with a Spaniard. Her Indian fiancée, Yaraví, committed suicide, and the girl in order to not betray her people never saw the Spaniard again, but sad and crying for her disaster, died. The mountains pitying her created a perpetual silhouette of her figure which can be seen from El Valle. Another attraction is the Macho waterfall and the Mozas waterfall, the Painted Stone, the Museum of El Valle, the Nispero Zoo, and the Sunday open market. El Caño is an archaeological site where pre-Colombian burials may be found. Close to El Caño is Nata. Santiago de Nata de los Caballeros is today the oldest inhabited city in Panama. Nata was the first city founded in the country's interior and one of the few cities that has not been moved from its original location. Pedro Arias Davila was the founder of the city which was used as a base from which to wage war against Chief Urraca and other native tribes. The name Nata may have its origins in the name of another chief. However there is another version of the story which claims the Spanish king found out that in this place were many disputes and corruption. He then sent 100 distinguished knights to maintain order and improve the city's image. From this story comes the name Nata de los Caballeros (The Best of the Knights), due to those blue-blooded knights that would be the cream of the crop of the city. We cannot fail to mention one of the colonial jewels of Panama, the Church of Natá de los Caballeros, an enormous white temple surrounded by a low fence with small shrines whose interior boasts a beautiful altarpiece from 1751.

In 1581 the city San Juan Bautista de Penonome was founded by Diego de Villanueva Zapata, yet the name comes from the name of a chief called Nome who fought against Spanish troops under the conquistador Badajoz. Badajoz, yearning for gold, followed Nome and tortured him to force him to admit where he kept his riches. The chief then died due to his serious wounds. It is said that on later passing by the place the Spaniard Espinosas found a sepulcher with a headstone engraved with the inscription: "Aquí penó Nomé (Here Nome was punished). On a curious note Penenome was the capital of the Panamanian isthmus until it was finally moved to the new city at the foot of Ancon Hill (Panama).

This province also offers such places as the Archaeological Museum of El Caño, the Cascades of Olá, the Távida Waterfall in Penenomé, the Penenomé Museum, and the artisanry market of La Pintada among others.